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It was estimated that 46.8 million people worldwide are living with dementia in 2015. This number will almost double every 20 years, reaching 74.7 million in 2030 and 131.5 million in 2050. Dementia is not curable today. Even though some drugs have been used in clinic researches, the drugs have side effects. Clinic studies show, people with fewer years of formal education are at higher risk for Alzheimer’s and other dementias than those with higher years of formal education. These results make us believe education, learning, mentally stimulating activities and memories have correlations from each other. In our previous studies, we defined memories as environmentally acquired information or signals (charges) stored or retained in the brain neurons (synapses). We modelled the long term memories (LTM) as consolidated (charged) proteins in the synapses. The charges may be discharged, therefore the memories may be lost because neurons are degenerated or died. Here, we firstly clarify learning is to acquire new information, not to repeat old information. We propose models to describe mechanisms of dementias caused by less mentally stimulating activities, and models of the education and learning to prevent, delay and/or treat the dementias. We believe the health oriented lifelong learning (HOLL) is the most effective way to precisely acquire the environmental information and maintain correlated memories in different knowledge fields as well as is a mental exercise that speeds up cerebral blood flow, nutrition supplies, O2 biochemical metabolism and produces the biological energy ATP and neuron chemic media in the synapses; and burn the over stored nutrients that may cause or induce the diseases. The more complicate and/or versatile the learning is, the stronger and/or longer the acquired memories can be maintained. Our HOLL models based on clinic trials data have not any side effect as long as the intensities are health oriented: moderate or mild. *Correspondence to: Kang Cheng, Biomedical and Biochemical Info physics, Science Research Institute, 205 Hana Road, Edison NJ 08817, USA, Tel: 732-2480790, E-mail: kangcheng.1@netzero.net

frontiers in drug, chemistry and clinical research

Modeling health oriented lifelong learning (HOLL) to prevent, delay and/or treat aging or aged dementias caused by less mentally stimulating activities