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Development of epithelial malignancies leads to well documented molecular and structural changes in the epithelium. Recently, it has been recognized that stromal biology is also altered significantly with preinvasive disease. Oral Squamous Cell Carcinoma comprises a bulk of all oral malignancies. In Oral Squamous Cell Carcinoma, cell invade the stroma in the form of islands, strands or sheets, which are embedded or surrounded by an extracellular matrix, thus producing reactive changes in the stroma. Reticulin fibers along with collagen fibers, is not only responsible for maintaining the functional integrity of tissues but is also thought to play an important role in pathogenesis and invasion in Oral Squamous Cell Carcinoma. In this study, reticulin fibers were studied histopathologically for the length, thickness, density of colour and uniformity of stain of in various grades of Oral Squamous Cell Carcinoma with Gomari silver reticulin stain. Thus, the present study helps in documentation of connective tissue changes in various grades of Oral Squamous Cell Carcinoma . Correspondence to: Ashwini Walke, Department of oral pathology and microbiology, Riyadh, Saudi Arabia, Tel: 9975771205; E-mail: ashwiniwalke2210@gmail.com

To study the length, thickness, density and staining intensity of reticulin fibers in various grades of oral squamous cell carcinoma