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Background: The requirement of luteal phase support in in vitro fertilization cycles is necessary. However, the route and the dose of progesterone is still debated. Recently a water-soluble injectable progesterone complex became available for subcutaneous administration. The purpose of this study was to see the effect of the water-soluble injectable progesterone complex (Prolutex)® in luteal phase support during in vitro fertilization – embryo transfer cycles in Saudi population. Methods: A retrospective cohort study, including the women who underwent IVF-ET treatment at KFSH & RC IVF unit from June 2017 to December 2017. The pregnancy rate in patients who received subcutaneous progesterone supplementation for luteal phase support after IVF-ET cycles were compared to the patients who received intravaginal Cyclogest. Results: A total of 447 patients underwent IVF treatment during the study period between two groups. There were 167 in Prolutex and 280 in Cyclogest groups. Live birth rates in patients who received Prolutex and Cyclogest were similar. Conclusion: Prolutex is safe and effective in supporting the luteal phase in IVF patients. *Correspondence to: Khalid Awartani, Reproductive Medicine, Department of Obstetrics and Gynecology, King Faisal Specialist Hospital and Research Centre Riyadh, Kingdom of Saudi Arabia, E-mail: kawartani@kfshrc.edu.sa

Subcutaneous progesterone (Prolutex) ® for luteal phase support in cycles of in vitro fertilization–embryo transfer- A retrospective cohort study