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Background: The aim of the research is to study of the formation of uteroplacental blood flow in threaten miscarriage at 11-13 weeks og gestation term among patients with a normal level of progesterone in the blood and in patients with hypoprogesteronaemia. Materials and methods: The study included two groups of primigravidas patients of gestation term from 11 to 13 weeks. The 1st Group – women with pregnancy at the background of threatened pregnancy interruption (n=84), the 2nd Group – women with uncomplicated pregnancy (n=47). In both groups the definition of progesterone level in blood was performed. Based on the obtained data, the 1st group was divided into two subgroups: 1st A subgroup with low level of progesterone in blood (n=31); the 1st B subgroup with normal level of progesterone (n=53). Uteroplacental blood flow investigation via improved dynamic flow mode (Advanced Dynamic Flow) was provided for all the patients, that helped to assess the state of blood flow of uterine and spiral arteries. Construction of three-dimensional image of the vessels’ architectonics was carried out using the 3D ultrasound. Results: In the group of patients with deficiency of progesterone in blood, a significant increase in the value of the pulsation index of spiral arteries (p=0.0001) was noticed. A negative correlation between the level of progesterone in blood and the characteristics of the blood flow of spiral arteries was detected. Conclusion: Deficiency of progesterone in the blood of pregnant women can prevent the formation of an adequate system of “mother-placenta-fetus”. Violation of the blood flow in the spiral arteries may be considered as the main feature of Doppler sign for threatened miscarriage and possible complications of gestational process at a later terms. Correspondence to: Julia E. Dobrokhotova, Professor, Doctor of Medical Science, PhD, Head of Department of Obstetrics and Gynecology, Medical Faculty, N.I. Pirogov Russian National Research Medical University, Moscow, the Russian Federation, 123100, Moscow, Shmitovsky proezd 12, 3; Tel: 8-(903)722-63-99, E-mail: pr.dobrohotova@mail.ru

clinical obstetrics, gynecology and reproductive medicine

Assessment of the forming uteroplacental blood flow in patients with threatened abortion on the background of progesterone deficit in the 1st trimester of pregnancy