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Morphogenesis is related to Candida albicans pathogenesis and nutritional/ environmental factors linked to eIF2-mediated translational regulation, modulated by Gcn2 and Gcn4, are common inducers of morphological changes. Here we show that C. albicans GCN2 knockout is less virulent to Caenorhabditis elegans and worms survive longer (p < 0.05) than control worms infected with wild-type yeast. Besides, C. albicans GCN4 knockout showed slightly reduced virulence to C. elegans when compared to controls (p <0.05). Interestingly, C. elegans decreased susceptibility to C. albicans GCN2 knockout correlates with its decreased filamentous growth and biofilm formation ability in amino acid rich media used to survival assays (p <0.001). We conclude that Gcn2 kinase, regulator of General Amino Acid control pathway (GAAC) and its target Gcn4 are important to C. albicans virulence in C. elegans model of infection. *Correspondence to: Viviane S. Alves, Universidade Federal de Minas Gerais, Av Antonio Carlos, 6627, ICB, Departamento de Microbiologia, Bloco F4, 171, Laboratorio de Biologia Celular de Microrganismos, Brazil, Tel: +55 31 34093018, Fax: +55 31 3409-2733, E-mail: gouveiava@ufmg.br

The eIF2 kinase Gcn2 modulates Candida albicans virulence to Caenorhabditis elegans