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Background: Cutaneous viral warts (non-genital) is an intractable disease, which are caused by infection with a type of Human Papilloma Virus (HPV). The virus is believed to enter the body through skin that has been damaged slightly. The other skin diseases which adjacent to cutaneous viral warts and destroy the skin barrier function may influent the prognosis of the warts. Objective: Classifying the other skin diseases in cutaneous viral warts and assessing their possible association with different kinds of cutaneous viral warts. Methods: Culling Center database from our hospital between May 2016 and May 2017, we retrospectively reviewed patients in whom “warts” had been diagnosed, and then calculated the other skin diseases adjacent to the warts. Results: 991 cases were assessed in the final analysis, including 230 plantar warts, 153 plane warts and 604 common warts, with which there are 143, 8 and 34 cases of skin diseases adjacent to them, respectively. The incidence of the skin diseases adjacent to plantar warts is much higher than in the other two type of warts. The number of treatments of the plantar warts which was combined with other foot disease is higher than that with no other foot diseases. Conclusions: Patients with foot skin diseases may be susceptible to infection of HPV. Limitation: A potential limitation to this study is sampling bias and lack of generalizability; this study was performed at district center hospital in China. Additional studies are needed to determine how these adjacent diseases change over time with various therapies. Correspondence to: Yanhua Liang, Department of Dermatology and STD, henzhen Hospital of Southern Medical University, Shenzhen, China, E-mail: liangdoctor@163.com