English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Substrate	  analogs	  are	  small	  molecules	  that	  aid	  in	  the	  understanding	  of enzyme	  structure-­‐function	  relationships.	  By	  careful	  design	  they	  can	  be	  utilized	  to probe	  the	  nature	  of	  the	  transition	  state	  in	  catalysis,	  and	  to	  assist	  in	  the	  process	  of rational	  drug	  design.	  Aminoacyl-­‐sulfamoyl	  adenylate	  transition	  state	  analogs	  (aa-­‐ AMS)	  are	  analogs	  of	  the	  aminoacyl	  adenylate	  reaction	  intermediate	  in aminoacylation	  by	  aminoacyl-­‐tRNA	  synthetases	  (aaRS)	  [16].	  To	  better	  understand the	  chemical	  mechanism	  of	  aaRS,	  aa-­‐AMS	  are	  used	  in	  crystallography	  experiments where	  x-­‐ray	  diffraction	  helps	  reveal	  interactions	  crucial	  to	  catalysis.	  Here	  we	  report the	  complete	  synthesis	  and	  purification	  of	  Ile-­‐AMS.	  The	  four-­‐step	  process	  proceeds via	  a	  sulfamoyl-­‐adenylate	  precursor,	  from	  which	  a	  library	  of	  aa-­‐AMS	  can	  then	  be generated	  by	  the	  addition	  of	  particular	  amino	  acids.	  After	  addition	  of	  the	  amino	  acid

Synthesis of Sulfamoyl??Aminoacyl Adenylate Analogs for use in Protein?RNA Structure Determination