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Psychological stress is common and contributes to many physical and mental health problems. Its effects are mediated by a complex neurobiological system centering in the brain with effectors including autonomic nervous system, hypothalamic-pituitary-adrenal axis, inflammatory system, and gene expression. A stressor pushes the human physiological system away from its baseline state towards a lower utility state. The physiological system may return towards the original state but may be shifted to a lower utility state. While some physiological changes induced by stressors may benefit health, chronic stressors usually have negative effects on health. In contrast to this stressor effect is the system’s resilience which influences its ability to return to the high utility attractor basin following a perturbation by increasing the likelihood and/or speed of returning to the baseline state following a stressor. Age-related cognitive decline is a major public health issue with few preventative options. Stress contributes to this cognitive decline, and mindfulness meditation (MM) is a behavioral intervention that reduces stress and stress reactivity in many health conditions. A randomized clinical trial was performed to determine if MM in older adults would improve measures of cognitive function, as well as psychology and physiology, and to determine what factors might predict who would improve. 134 at least mildly stressed 50-85 year olds were randomized to a MM intervention or a wait-list control. Outcome measures included a broad cognitive function battery with emphasis on attention and

A Systems Approach to Stress and Resilience in Humans: Mindfulness Meditation, Aging, and Cognitive Function