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i Acknowledgements v List of Tables ix List of Figures x List of Abbreviations xii 1.0 Introduction 1 1.1 General introduction to Streptomyces and secondary metabolites 1 1.2 The life cycle of Streptomyces 2 1.3 Fatty acid biosynthesis in Streptomyces coelicolor 3 1.4 Undecylprodiginine biosynthesis in Streptomyces coelicolor 5 1.5 The interface between fatty acid and undecylprodiginine biosynthesis in Streptomyces coelicolor 8 1.6 Aims of the current research 9 2.0 Streptomyces coelicolor RedP and FabH enzymes, initiating undecylprodiginine and fatty acid biosynthesis, exhibit distinct acyl-CoA and malonyl-acyl carrier protein substrate specificities 12 2.1 Summary 12 viii 2.2 Introduction 13 2.3 Materials and Methods 16 2.4 Results and Discussion 19 3.0 Characterization of FabG and FabI of the Streptomyces coelicolor, Dissociated Fatty Acid Synthase 29 3.1 Summary 29 3.2 Introduction 30 3.3 Materials and Methods 35 3.4 Results and Discussion 44 3.5 NMR spectral data of the intermediates and final compounds 63 4.0 Conclusions and recommendations for future work 98 References 102

Enzymatic Control of the Related Pathways of Fatty Acid and Undecylprodiginine Biosynthesis in Streptomyces coelicolor