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Radix Stephaniae tetrandrae, dry roots of Stephaniae tetrandrine S. Moore (Menispermaceae), is officially and traditionally used as an analgesic and anti-hypertension drug in China. The main chemical constituents in radix Stephania tetrandrae are tetrandrine (Tet) and fangchinoline (Fan) [1]. Tet has an antiadherent effect that might result from its inhibition of Ca 2+ influx and reactive oxygen species formation, resulting in suppression of up-regulation of Mac-1 and, in turn, neutrophil adhesion to fibrinogen [2]. In the past several years, important progress had been made in the study of the mechanisms of effect of Fan on some diseases. Lin Ty et al. reported that Fan inhibited glutamate release from rat cerebral cortex nerve terminals and had been shown to possess neuroprotective properties [3]. Fan has anti- inflammatory effects [4] and antioxidant activity [5]. Most recently, Zhang YH et al. reported that Fan inhibits proliferation and cells cycle progression of aortic vascular smooth muscle cell through inhibition of ERK1/2 activation and c-fos expression [6]. However, the anti-tumor activity of Fan in breast cancer is still unknown. Objective: This study was purposed to investigate the effect of Fangchinoline (Fan) on the regulation of tumor growth and apoptosis in vivo. Methods: Immunohistochemistry (IHC) was used to determine the protein levels of p27, CD117 and ki67 in tumor tissue of xenograft. After treatment of Fan, the morphologic changes were observed by DAPI staining, Hoechst staining and TUNEL detection under fluorescent microscopy. The protein expression of Bax, Bcl-2 active Caspase-3 and cytochrome-c were measured by Western blotting.

Fangchinoline Inhibits Breast Tumor Proliferation and Induces Apoptosis in MDA-MB-231 Cell Line in Vivo