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The veterinarian must confront many situations when working with thoroughbred horses in which he must solve and make decisions that lead to balance between the animal and trainer / owner of the horse, the above should be resolved in an ethical and professional manner. The management and demand levels to which thoroughbred horses are subjected leads to an organic stress reaction absolutely necessary to maintain homeostasis with an appropriate allostatic load depending the systemic demand they undergo. However, if these conditions are inadequate such as, insufficient training, overtraining, increased levels of competition in distance and frequency, stressful situation becomes a chronic condition that seriously compromises the animal's homeostasis thereby acting as a predisposing factor that could trigger in some cases a wide range of diseases that may compromise the performance and the life of the animal in severe cases (Infectious diseases, upper airway diseases, musculoskeletal diseases, among others). Although catecholamines and cortisol have a positive effect on the immune system by promoting migration and maturation of immuno competent cells, these substances when are chronically sustained over time at high levels produces an immunosuppressive response. Briefly, the glucocorticosteroids (cortisol) acts predominantly on type II cell receptors which results in stimulation of anti-inflammatory protein synthesis and decreases the maturation and migration of immune cells. Additionally, the chronic levels of catecholamines significantly modify the behavior of leukogram which also shows decreased immune protection. It is known that chronic stress inhibits the humoral and cellular immune response, decreases the proliferation, migration and T cell cytotoxicity, reduced antibody production, reduce the synthesis of proinflammatory cytokines and interleukins etc. This may be prevented by a rational and appropriate use of animals in competition which although it is dependent on a great number of variables an important factor is the role played by veterinarians who have the responsibility to authorize or recommend animal for competitions.

Thoroughbred Race Horses Management: A Key Role of the Veterinarian