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Significantly fewer of the patients treated with EC-MPS required dose reductions than MMF patients, especially early after transplant at 1 month (2.9% vs. 16.4% of patients, respectively, p=0.008) and 3 months (7.3% vs. 29.5% of patients, p=0.001). In addition, there were almost twice as many episodes of acute allograft dysfunction and biopsy-proven rejection in the MMF-treated group compared with the EC-MPS-treated group. Otherwise, the adverse events and tolerability profiles of the two agents were very similar and not significantly different at six months.

Drug Tolerability and Outcomes in Kidney Transplant Recipients Treated with Two Formulations of Mycophenolic Acid