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In this research, STEAM education program based on life science was developed for verifying the effect in science-related affective domain and creativity of high school students. To achieve this, through analyzing combined types of integration, three dimensional framework for STEAM program were developed. The main areas of circulation, plants, genetics, stimulation and response in parts of life science were chosen. Then, technology, engineering, art and mathematics were integrated in those main areas. The study results are like the following: First, STEAM education program based on life science showed improvement in science-related affective domain of high school students. Students’ confidence (p=.008), interest (p=.003) and value (p=.010) are also significantly increased. Second, it also showed the effectiveness in improving creativity. After applying the program to the students, standard scores of creativity (p=.000) and of its subcategory elements – fluency (p=.000), originality (p=.000) and exquisiteness (p=.003) – increased and the result was statistically meaningful. Third, according to students’ gender, its effects appeared differently. Male students valued science higher than female students. On the contrary, female students showed higher scores in creativity, fluency and originality.

The Effects of STEAM Program based on Life Science for Science-Related Affective Domain and Creativity in High School Students