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Entamoeba histolytica cell migration is essential for the development of human amoebiasis (an infectious disease characterized by tissue invasion and destruction). The tissue inflammation associated with tumour necrosis factor (TNF) secretion by host cells is a well-documented feature of amoebiasis. Tumour necrosis factor is a chemoattractant for E. histolytica , and the parasite may have a TNF receptor at its cell surface.

In Entamoeba histolytica, a BspA family protein is required for chemotaxis toward tumour necrosis factor