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This article was migrated. The article was not marked as recommended. Focus in traditional practical courses has always been on imparting technical knowledge. However, significance and application often are unclear for students, leading to low motivation. Thus, a practical course that is clinically relevant to students in the 4th semester was set up in biochemistry so that: a) a clear link to the clinical work can be identified, b) the roles of the physician, as set out in the German National Competence-based Learning Objectives Catalogue for Undergraduate Medical Education (NKLM), are covered in the best possible manner, and c) the scientific basis has a high importance.The newly established course covers key points of research work in 4 days, beginning with a fictitious case study. Samples of (artificial) urine and blood are used to diagnose sickle cell anemia and malaria, and their molecular basis is analysed using bioinformatic tools. Students learn how to research and discuss academic publications. Working in groups, they establish a concept using gene therapy to explore how a higher expression of fetal hemoglobin in erythroblasts could be induced using RNA interference to attenuate progression of the disease. Instead of recording the findings in a traditional manner, the students work together in groups to produce a manuscript of their results, which is critically examined to assess the suitability for being published.The semester cohort was randomly allocated to the newly established (n=79) and the traditional (n=57) practical course. Both courses were comparatively evaluated. The newly designed course received an overall assessment of 1.4, which was significantly better than the traditional course which received an overall assessment of 2.9.During the next years, nearly all subjects of the preclinical section will be challenged to find ways of combining NLKM requirements and technical knowledge. The concept presented here may serve as a model to be readily adapted to other fields.

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Competence-based education in the example of a biochemical practical course with clinically relevant content for undergraduate medical students in the fourth semester of the preclinical section