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Background: Premature birth is currently a serious problem for obstetrician-gynecologists. Most researcher consider this problem from the standpoint of metabolome disturbances. Aims: determination of the level of bioactive regulators and organic acids with physiological and complicated pregnancy, ending in timely and spontaneous preterm labor, in blood serum and amniotic fluid and revealing the presence of their relationship for the development of premature birth and the condition of newborns. Materials and methods : 72 women were examined, 40 of them with a physiological pregnancy (control group) and 32 with premature labor (the main group). All studies were carried out in the blood serum and amniotic fluid of women of these groups. The content of TGFβ was determined by the method of solid-phase enzyme immunoassay. Identification and quantitative determination of citric and succinic acids were carried out by the method of capillary electrophoresis. Results: TNFα production in the blood serum of women with preterm labor, decreased by 38%, and the level of citric and succinic acids by 33 and 30%, respectively, compared with the control group. In the amniotic fluid the level of TNFα was increased 2.5 times and TGFβ ― 2.2 times, citric acid ― 79%. Conclusions: The revealed imbalance in the level of cytokines and organic acids studied in that biological fluids can evidently affect the fetal condition, which can be considered as possible markers of perinatal injuries and prognostic indicators of the state of the newborn.

Peculiarities of Changing Bioregulators and Organic Acids in the Serum of Blood and Amniothic Fluid of Women with Spontaneous Preterm Labor