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This paper focused on the literature survey of the use of flexible manufacturing system design and operation problems on the basis of simulation tools and their methodology which have been widely used for manufacturing system design and analysis. During this period, simulation has been proving to be an extremely useful analysis and optimization tool, and many articles, papers, and conferences have focused directly on the topic. This paper presents a scenario the use of simulation tools and their methodology in flexible manufacturing system from a period 1982 to 2015. Keywords—Flexible manufacturing system (FMS), modeling, simulation, software.