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In our studies on the phytochemistry and biological activities of Croton tonkinensis Gagnep. (Euphorbiaceae) oriented by traditional medicine interesting biological activities of the plant were demonstrated in correlation with the ent-kaurane-type diterpenoid constituents. The high accumulation of the active principle ent-18-acetoxy-7β-hydroxykaur-16-en-15-one ( 1 ) led to our recent study on the chemical modification of this lead compound. In this paper the transformations of 1 into several derivatives by hydrolysis, acetylation, and oxydation were reported. The cytotoxic activity against of the transformation products Hep-G2 and LU cells was evaluated. Keywords:  Croton tonkinensis ; Euphorbiaceae; ent-kaurane-type diterpenoid; chemical transformation; cytotoxicity.

Chemical transformation of Ent-Kaurane-type diterpenoids from Croton tonkinensis Gagnep. I - Hydrolysis, acetylation, and oxydation of Ent-18-acetoxy-7beta-hydroxykaur-165-en- 15-one