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Trang To (Ixora duffii) belongs  to  Ixora genus in the family Rubiaceae. The in vitro total antioxidant and anti-inflammatory capacity of Trang To methanol leaf extract was investigated by using phosphomolypdenum method and Bovine serum albumin denaturation test. The results have shown that Trang To methanol leaf extract possessed relatively high antioxidant activity, the value OD0,5 of Trang To (OD0,5 = 15,551 ± 0,344 μg / mL) was compared to that of the standard, trolox (OD0,5=2,315±0,083 μg/mL). The anti-inflammatory effect of Trang To leaf extract obtained in Bovine serum albumin denaturation test (EC50= 6,03±0,12μg/mL) was comparable to reference drugs, diclofenac sodium (EC50= 0,57±0,21µg/mL). The hepatoprotective activity of the methanol leaf extract of Trang To was investigated in mice which their livers were damaged by carbon tetrachloride (CCl4) mixed in olive oil (1: 4) at dose 2.5 mL/kg body weight/ day. The standard hepatoprotective agent is silymarin, was used at dose 16 mg/kg body weight during 4 consecutive weeks. The results of Trang To leaf extract was examined at three different doses 100, 200 and 400 mg/kg body weight all showed the effective reduction of transaminase enzyme levels in serum, with ALT levels (104,80±14,84 U/L, 84,20±20,02 U/L, 45,00±21,06 U/L) and AST levels (137,40±26,30 U/L, 119,20±6,40 U/L và 88,80±14,62 U/L) when increasing of the extract dose, respectively. In addition, Trang To leaf extract also improved the oxidative stress status in the liver through effective reduction of MDA level and increasing of GSH level in the liver. Observation of the microscopic cross section of liver tissue revealed that the mice treated with Trang To leaf extract had significantly improvement in liver tissues compared to the non-treated control group, these also showed similar results as silymarin at dose 16 mg/kg body weight. The results of this study demonstrated the efficacy of Trang To leaf extract in antioxidant and hepatoprotective activity.

academia journal of biology

STUDY ON ANTIOXIDANT, ANTI-INFLAMMATORY AND HEPATOPROTECTIVE ACTIVITIES ON CARBON TETRACHLORIDE – INDUCED HEPATIC DAMAGE IN MICE OF TRANG TO (Ixora duffii) LEAF EXTRACT