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During the search for antidiabetic agents from natural sources, four biflavones including amentoflavone (1), robustaflavone (2), cupressuflavone (3), and 3,8′′-biapigenin (4) have been isolated from the methanol extract of Vietnamese medicinal plant Selaginella tamariscina by using combined chromatographic experiments. The chemical structures of isolated compounds were determined and elucidated by the interpretation of NMR spectral data, mass spectra as well as comparison with data from the literature. All isolated compounds showed significant stimulatory effects on 2-NBDG glucose uptake in 3T3-L1 adipocyte cells. At a concentration of 10 μM, compounds 3 and 4 exhibited potential stimulatory effects by 1.47 and 1.44 fold of inductions as compared with the control (DMSO), respectively. The result suggests that these biflavonoids maybe potential as insulin mimetics for developing antidiabetic agents.

INSULIN-MIMETIC BIFLAVONOIDS FROM A VIETNAMESE MEDICINAL PLANT SELAGINELLA TAMARISCINA