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“Rational use of medicaments” is one of the most considerable paradigms in the pharmaceutical region. All of pharmaceutical researches might be performed to promote this. Chromatographic analysis of medicaments in biological fluids is often required to accomplish the rational use of medicaments and related compounds [1]. Nowadays, any useful information such as quality control, pharmacokinetics, pharmacodynamics, pharmacology and toxicology of medicament are always obtained with chromatographic analysis. Therapeutic drug monitoring based on determination of medicaments is one of the representative examples. Among the separation techniques employed for medicament or related compounds analyse such as thin−layer chromatography, gas chromatography, high−performance liquid chromatography (HPLC), capillary electrophoresis and capillary electrochromatography, HPLC and GC have been proven to be the most popular, because these can offer better sensitivity, selectivity and applicability. In addition, most medicaments and related compounds as well as endogenous components in biological samples are commonly non−volatile and polar compounds. And HPLC is become widespread, thus it is the most suitable among chromatographic techniques for their analysis. If the target molecule does not have desirable properties for spectrometric or luminometric analysis, a labeling reaction is needed to introduce the properties in these molecule. A labeling reaction is commonly achieved by the selective reaction between the functional group of the analyte and that of the labeling reagent. Labeling serves to improve the sensitivity, selectivity and the separation behavior. In our previous studies, 4−(4, 5−diphenyl−1H −imidazol−2−yl)benzoyl chloride (DIB−Cl) was one of the most powerful fluorescent labeling reagents and has been applied to determine the varied medicaments such as 3,4−methylenedioxymethamphetamine (MDMA) and its metabolite [2, 3], and morphine (Mor) [4]. Especially, the methods for MDMA were successfully showed applicability to the several biological samples such as human hair [3] and plasma, rat brain and blood microdialysates [2]. To date, many Focusing Review

Development and practical application of HPLC methods for medicaments and related compounds