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DOI: 10.15580/GJBS.2016.3.051816091 Anti-inflammatory effect of Pleurotusostreatus (oyster mushroom) aqueous extract was studied. The extract was prepared using a novel design of relative moisture content to determine the dry weight of the extract. Thirty-five albino rats (grouped into five group sat seven animals per group) were used for the experiment. The five groups were administered oral doses of Pleurotus ostreatus at the following dosages: Group one (control with 1ml normal saline) groups two, three and four had treatments with Pleurotus ostreatus at 100, 200, and 400mg/kg respectively, while group five was treated with Aspirin (a standard drug) at 15mg/kg as positive control. Egg albumin (0.1ml) was injected at the planter surface of the right hind paw and with the aid of a locally constructed plesthymograph (another novel approach), the paw volume was recorded at the 0,30,60,90and 120 minutes after albumin injection. The result indicated that the aqueous extract has a significant (P<0.05) inhibitory effect on rats paw inflammation. The five groups were not significantly different at the time ‘0’ but at 30minutes, treatment 4 was significantly (P<0.05) different from the control (group one),while at 60minute to 120 minutes all the treatment groups were significantly (P<0.05) different from the control. During the analysis of percentage inhibition, it was observed that with 100mg/Kg treatment, there weren8.33, 53.84, 57.69 and 67.85% inhibitions at 30, 60, 90 and 120minutes intervals respectively after albumin injection. Treatment with 200mg/kg of the extract resulted in a percentage inhibitions of 45.83, 76.92, 84.61 and 83.92 at 30, 60, 90 and 120 minutes intervals respectively. The highest inhibition was recorded with 400mg/kg with a 103% inhibition at 120minutes after injection. The result buttressed that aqueous extract of Pleurotus ostreatus has a significant antiinflammatory property on right hind paw of rats. Submitted: 18/05/2016 Accepted: 28/05/2016 Published: 27/06/2016

Anti-Inflammatory Effect of Pleurotus ostreatus (Oyster Mushroom) Aqueous Extracts on Rattus norvegicus (Albino Rats)