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One of the reasons of high pediatric mortality in developing countries, sickle cell disease is gradually emerging and is becoming a public health problem in many countries where it is rife. In Algeria the incidence is 2.7%. The management of sickle cell disease is increasingly better codified now thanks to better knowledge of the condition. It takes into account not only currently accepted universal principles but also the realities specific to our country. Purpose: to share with health care professionals our therapeutic attitude during main acute complications as well as during the inter3critical phase of sickle cell disease in Algerian children. Clinical cases. In this article, we presented three clinical cases concerning two adolescents and a two3year3old infant, carriers of major sickle cell syndrome, who were hospitalized for severe forms. Conclusions. Providing right care for children with sickle cell disease could help prevent or improve many complications associated with this disease and allow them to lead healthier and more productive lives. Our patients were presented late. These cases revealed the problematic nature of early diagnosis, regular follow-up and early detection of complications in SCD patients especially with asymptomatic osteonecrosis of the femoral head. The research was carried out in accordance with the principles of the Helsinki declaration. The informed consent of the patients was obtained for conducting the studies. No conflict of interest was declared by the author. Keywords: sickle cell disease, acute anemia, stroke, osteonecrosis.

Clinical and therapeutic aspects of sickle cell disease in three clinical cases