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Purpose — study of the severity of secondary sexual characteristics in girls with general and genital infantilism in the early reproductive period. Materials and methods. 150 girls with general and genital infantilism were examined. All examined girls underwent clinical, functional, hormonal, biochemical, radiological, genetic and laboratory tests. The average age of girls was 19.56±0.13 (17–22) years. The average weight of the examined was within 55.37±1.56 (32–98) kg, height 1.57±0.13 (1.36–1.71) m. The body-mass index was 22.5±0.48 (15–48). The severity of secondary sexual characteristics was assessed according the J. Tanner scale. Results and conclusions. It was found that adolescents with general infantilism (hypogonadotropic hypogonadism) have a significant delay in the development of secondary sexual characteristics against the background of mild hirsutism (р&lt;0.05). In Patients with genital infantilism (hypergonadotropic hypogonadism), significant axillary and suprapubic hair growth at the background of poor development of the mammary glands was noted. Also the moderate degree of hirsutism was confirmed. With normogonadotropic hypogonadism, the development of secondary sexual characteristics corresponds to similar indicators of practically healthy girls. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of these Institutes. The informed consent of the patient was obtained for conducting the studies. The authors declare no conflicts of interests. Key words: general infantilism, genital infantilism, hypogonadotropic hypogonadism, normogonadotropic hypogonadism, hypergonadotropic hypogonadism, hirsutism.

Features of sexual development in girls with general and genital infantilism in the early reproductive period