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White or gray areas show the electron density obtained using cryogenic electron microscopy (cryo-EM) and colored areas represent protein conformations, where green corresponds to the receptor-binding domain Reprinted with permission from Reference 4 © 2019 Springer Nature (c) Schematics of a smartphone-based imaging device and quantum-dot (QD)-based fluorescent reader developed for Zika virus detection, with one stripe indicating its presence (test line) and one stripe indicating the test is working (control line using an established antibody;goat anti-mouse IgG) A study showed that entire cells and their interiors could be imaged in 3D with a resolution of 8 nm 3 To achieve this, a cell was first labeled with fluorescent markers, vitrified by high-pressure freezing to preserve its structure, and imaged by cryogenic light microscopy In a study using mixtures of polyacrylonitrile with tetraethoxysilane and ammonium tetrathiomolybdate salts, membranes were developed that could block more than 98% of Semliki forest virus, another RNA virus of ∼50-nm diameter (Figure 1d) 7 The efficiency of the membranes was improved by the presence of the salts that increased the surface energy and roughness of the individual polymeric fibers

How can materials science contribute to fighting against the new coronavirus?