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espanolEl objetivo de este estudio es hacer una revision de la fragmentacion celular y correlacionarla con la calidad embrionaria. Para ello se realizo una busqueda sistematica de la literatura sobre «fragmentacion embrionaria» y «calidad embrionaria». Para este estudio se incluyeron estudios de parametros morfologicos por observacion convencional asi como los estudios de morfocinetica mediante tecnologia time-lapse. En primer lugar, se realizo una busqueda en Cochrane, MEDLINE, MEDES, ENFISPO y EMBASE de todo tipo de articulos (todas las publicaciones hasta diciembre de 2016). Trabajos sobre fragmentacion embrionaria, parametros morfologicos embrionarios y calidad embrionaria, tasa de fragmentacion, tasa de implantacion y fragmentacion embrionaria, morfocinetica embrionaria e implantacion embrionaria. Se revisaron los resumenes y se identificaron articulos potencialmente relevantes. De los 50 articulos revisados, 10(20%) fueron ensayos aleatorizados controlados, 21(42%) estudios epidemiologicos observacionales, 8(16%) estudios experimentales, 11(22%) recomendaciones internacionales. Fueron descartados 20(40%) estudios por no ser randomizados y 21(42%) por tratarse de estudios de investigacion basica, trabajos de revision o estudios observacionales. Finalmente se seleccionaron 10(20%) articulos para la revision por tener relacion directa con el objetivo de la revision. La revision de los articulos seleccionados relaciona el parametro de fragmentacion embrionaria con otros parametros morfologicos, no considerandolo como unico indicador de una buena calidad embrionaria, valorando el conjunto de los parametros morfologicos considerado EnglishThe aim of the present study is to review cell fragmentation and to correlate it with embryonic quality. For that, a systematic search of the literature on “embryonic fragmentation” and “embryonic quality” was carried out. For this study, we included morphological parameters researches by conventional observation as well as morphokinetic researches using time-lapse system. First, we searched for all types of articles (all publications until December 2016) in Cochrane, MEDLINE, MEDES, ENFISPO and EMBASE. Moreover, we researched for works on embryonic fragmentation, embryonic morphological parameters and embryonic quality, fragmentation rate, implantation rate and embryonic fragmentation, embryonic morphokinetic and embryonic implantation. Abstracts were reviewed and it was identified potentially relevant articles. Of the 50 articles reviewed, 10 (20%) were randomized controlled trials, 21 (42%) observational epidemiological studies, 8 (16%) experimental studies, 11 (22%) international recommendations; 20 (40%) studies were discarded because they were not randomized and, also, 21 (42%) because they were basic research studies, revision studies or observational studies. Finally, 10 (20%) articles were selected for review because they were directly related to the objective of the review. The review of the selected articles correlates the parameter of embryonic fragmentation with other morphological parameters, not considering it as the only indicator of good embryonic quality, evaluating the set of morphological parameters considered.

Morphological aspects in embryonic development: Fragmentation and its relationship with embryonic quality. Bibliographic review