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Growth failure is a common feature of children with HIV-1 infection. Clinical efficacy of highly active antiretroviral therapy (HAART) in children has been well documented in developed countries, but only few data from developing countries. Highly active antiretroviral therapy shows improvement clinical outcome, immune status, growth parameters in HIV infected children, therefore, decrease morbidity, death and improve quality of life children infected with HIV. The objective of this study was to determine nutritional status improvement of child with HIV-1 infection in 12 months HAART in Sanglah Hospital Denpasar. A retrospective cohort study was conducted at Allergy-Immunology Division/ Department of Child Health, Udayana University Medical School/Sanglah Hospital Denpasar in July 2013. The growth differences before and after HAART was analyzed by paired t-test using SPSS program. A total of 31 children were analyzed. Generally, rerata parameters of nutritional status were increased at any period of measurement. Changes of nutritional status is seen by comparing the nutritional status parameters within a period of 3 months up to 12 months of observation. There were increasing in the mean of weight/age (W/A) from baseline (-2.30) to 12 weeks (-1.61) (mean difference 0.69; 95% CI 0.37 to 1.00; P<0.001), from 12 weeks (-1.61) to 24 weeks (-1.34) (mean difference 0.27; 95% CI 0.09 to 0.45; P=0.003), from 24 weeks (-1.34) to 36 weeks (-1.09) (mean difference 0.25; 95% CI 0.05 to 0.45; P=0.016) and from 36 weeks (-1.09) to 48 weeks (-1.02) (mean difference 0.07; 95% CI -0.07 to 0.20; P=0.351). The mean of height/age (H/A) were also increasing from baseline (-2.85) to 12 weeks (-2.60) (mean difference 0.25; 95% CI 0.01 to 0.50; P=0.049), from 12 weeks (-2.60) to 24 weeks (-2.22) (mean difference 0.38; 95% CI 0.01 to 0.76; P=0.047), from 24 weeks (-2.22) to 36 weeks (-1.76) (mean difference 0.46; 95% CI 0.15 to 0.77; P<0.001), but from 36 weeks (-1.76) to 48 weeks (-1.84) were decreasing (mean difference -0.08; 95% CI -0.31 to 0.14; P<0.001). It can be concluded that HAART has a positive effect on children’s growth in 12 months of observation in the form of an increase in generally W/A and H/A from time to time.

Nutritional status improvement of child with hiv-1 infection within 12 months highly active antiretroviral therapy in Sanglah Hospital Denpasar