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Objective: Myrmecodia pendens is often used as a traditional medicine to treat various diseases. A previous study showed that ethanol extract of sarang semut plant (hypnophytum furmicarum jack) 4.65 mg was effective in fastening establishment of socket granulation tissue after tooth extraction; likewise, the myrmecodia pendens at 3% also fastens the healing process of soft-tissue wound after tooth extraction. The aim of this study is to assess the effect of ethanol extract of 10% myrmecodia pendens on the expression of TGF-β1 and determine the number of osteoblasts that remain after tooth extraction. Material and Methods: This study used 24 male marmots divided into 2 groups. All of the groups were extracted in the 1st left-incisor mandibula and 0.1 ml of 0.5% CMC was applied into the socket control group. The treatment group was given 0.1 ml ethanol extract of myrmecodia pendens 10% dissolved with CMC 0.5%. On day 3, 7, 14 and 21, marmots were decapitated and histopathologic preparations were observed to study the expression of TGF-β1 and the number of osteoblast cells. Data were analyzed using Kruskall–Wallis test with a probability p < 0.05. Results: Based on the Kruskal–Wallis test, there was a significant difference in the TGF-β1 expression and the number of osteoblast cells after the administration of ethanol extract of myrmecodia pendens between the control group and treatment group treatment (p < 0.05). Conclusion: The ethanol extract of myrmecodia pendans can fasten the healing of the wound resulting from tooth extraction; it accelerates the healing process by increasing the expression of TGF-β1 and the number of osteoblast cells.

journal of dentomaxillofacial science

The effect of ethanol extract of myrmecodia pendens to tgf-β1 expression and osteoblast cells after tooth extraction (the experimental research on cavia cobaya)