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Objective: Tooth extraction is a process of removing a tooth from the alveolar process, which will always cause bleeding. Bleeding usually occurs as a result of higher pressure in the blood vessels than outside the blood vessel. In Indonesia, many plants are used as herbal medicines. Binahong (anredera cordifolia [tenore] steenis) contains flavonoids, terpenoids, essential oils, tannins. Soursop (annona muricata l.) leaf contains flavonoids, triterpenoids, saponins, polyphenols and tannins. The purpose of this study is to determine the effectiveness of binahong leaves extract, soursop leaves, combination of binahong and soursop leaves extract on the hemostasis process in cuts of mice. Material and Methods: This research was conducted at the Phytochemicals Laboratory Faculty of Pharmacy and Entomology Laboratory Medical Hasanuddin University. This research is a laboratory experiment with post-test only with control group design. First stage involved the making of binahong and soursoup leaves extracts using maceration techniques. Male mice were adapted for seven days. Treatment on day 8 included cutting the tail measuring as much as 1 cm in the length from the tip of the tail. Bleeding time is calculated after dipping the tip of tail into the extract for 5 seconds until there was no blood dripping on gauze pads. Data were analyzed using Kruskal–Wallis test followed by Mann–Whitney U test. Results: Binahong leaves extract, soursop leaves extract and combination of binahong and soursop leaves extracts affected hemostasis on cuts of male mice (mus musculus). Conclusion: Combination of binahong and soursop leaves extracts has the best effectiveness.

journal of dentomaxillofacial science

Effectiveness of binahong leaves extract, soursop leaves extract and combination of binahong leaves and soursop leaves extract on hemostasis in cuts of mice