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Propolis, the resinous hive product by bees, is important in the defence of the hive. It is know that extract of propolis exhibits such pharmacological activities as antimicrobia, antiviral, antifungal, anti-inflamatory, immunostimulatory and promote wound healing. The objective of this study was to investigate the influence of the propolis on the formation of collagen in the wound healing process of the subcutan injury of mice that were induced with Actinobacillus actinomyctemcomitans (A.actinomyctemcomitans) This study applied 24 female BALB/c mice of 2 3 months of age with the weight of 20 -30 grams. On the first day the whole population were injected with A.actinomyctemcomitans subcutanly. The second day mice were randomly devided into two groups that was the group with special treatment and the controlled ones. The group under treatment were given the extract of propolis 100 mg/kg body weight every day. While the controlled ones were only given aquades. Histological observation was conducted upon each group on the third, seventh and fourteenth days after A. actinomyctemcomitans injection. There-suits of the observation was based on the density collagen fiber. The data obtained then analyzed by using Mann-Whitney U test. The results of the present study indicated that the administration of 100 mg/kg BWpropolis peroral may stimulate collagen synthesis.

journal of dentomaxillofacial science

PENGARUH PROPOLIS TERHADAP KOLAGENISASIPADA PROSES PENYEMBUHAN LUKA SUBKUTAN PUNGGUNG MENCIT YANG DIINDUKSI BAKTERI ACTINOBACILLUS ACTINOMYCETEMCOMITANS