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The hormone testosterone in male decrease by the aging process, resulting decreased in mRNA expression of androgen receptors in penile tissue. The decline of androgen receptor mRNA expression penis, resulting atrophy in the erectile tissue and causing complaints on sexual function and male reproductive organs. The hormone testosterone modulates the proliferation of erectile tissue through regulation of androgen receptors, but there is little known about the effect of testosterone replacement therapy on the mRNA expression of Androgen Receptor in penile. The purpose of this study was to prove administration of testosterone replacement therapy can increase the mRNA expression of AR in castrated adult rat penile. The research design used Randomized Post Test Only Control Group Design. The study was conducted at the Laboratory Histology of Udayana University for 12 weeks in 36 adult rat castrated which were divided into 2 groups; control group and treatment group. The control group was given an injection of aquabidest 18μl/week intramuscular and the treatment group was given testosterone injections 4,5mg/250grBB/week intramuscular. After 28 days all rat were euthanized, their penile was taken for examination mRNA expression of AR. mRNA expression of AR measured by using real time PCR method. Data were analysed with tindependence test. mRNA expression of AR for both group were statistically significant with p value = 0,001 (p<0,05). The conclusion of this study was that testosterone replacement therapy increased expression mRNA androgen receptor in castrated adult rat penile.

intisasi sains media

Terapi Sulih Testosteron Meningkatkan Ekspresi Messenger Ribonucleaic Acid (mRNA) RESEPTOR Androgen pada Penis Tikus Wistar (Rattus norvegicus) Dewasa yang Dikastrasi