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Background: Birth asphyxia is a serious clinical problem worldwide. There are many reasons a baby may not be able to take in enough oxygen before, during, or just after birth. Birth asphyxia is the inabiity of neonates to start breathing spontaniously right after birth. Objective: This study was designed to assess the risk factors of birth asphyxia in neonates in Wangaya General Hospital. Methods: It is a case control study. The data of the newborn and mother was retrospectively collected from medical record in Wangaya Regional General Hospital between November 2018 to March 2019. It uses consecutive sampling. Bivariate analysis using chi square and multivariate analysis using logistic regresssion. Results: Bivariate analysis of risk factors of birth asphyxia that are studied are: low birth weight p value 0.000 (OR: 30.118); Number of birth p value 0,013 (OR 4,025); Prematurity p value 0.001 (OR 18.286); PROM p value 0.751 (OR 1.508); preeclampsia p value 1.000 (OR 0.804); and Cesarean Section p value 0.218 (OR 0.479). From multivariate analysis, the result was low birth weight p value 0.020; number of birth p value 0.003; prematurity p value 0.766; caesarean section p value 0,028. Conclusion: Risk factor of birth asphyxia in Wangaya General Hospital are low birth weight; number of birth (Primipara); and caesarean section. Keyword: birth asphyxia, risk factors, denpasar, neonates Cite This Article: Kurnia, B., Suryawan, I.W.B., Sucipta, A.A.M. 2020. Faktor yang mempengaruhi kejadian asfiksia neonatorum di RSUD Wangaya Kota Denpasar. Intisari Sains Medis 11(1): 378-381. DOI: 10.15562/ism.v11i1.548