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Background: Chronic rhinosinusitis is a chronic inflammation of the nasal mucosa and paranasal sinuses that can occur due to multifactorial and affect the quality of life of the sufferer. IL-8 is a proinflammatory cytokine that can significantly increase in chronic rhinosinusitis. Standard therapy and nasal washing with saline isotonic can reduce symptoms that complained of the patient and as well as the effect on changes in interleukin-8 as a proinflammatory mediator. This study aimed to determine the effectiveness of nasal irrigation with NaCl 0.9% against IL-8 level and quality of life in chronic rhinosinusitis patients. Methods: This study is an experimental study with a pre-post test control group design. The subject of the study was 30 people divided into two groups with simple randomisation, each group of 15 people in which the control group received standard therapy and treatment group received standard therapy and nasal irrigation with saline isotonic for two weeks. Quality of life assessment was conducted with SNOT-22 and interleukin-8 examination before and after therapy in each group. Results: There was no significant difference in SNOT-22 (p=0.227) of both groups before and after therapy. There was a significant difference in the ear and facial symptoms (p=0.025) and psychological (p=0.043) of both groups before and after therapy. Conclusion: Standard therapy and nasal washing with saline isotonic in patients with chronic rhinosinusitis give a better effect compared to standard therapy without nasal washing with saline isotonic in terms of inhibiting elevated interleukin-8 levels.

Effectiveness of nasal irrigation with isotonic saline against interleukin-8 levels and quality of life in chronic rhinosinusitis patients