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Heart failure is a debilitating disease with increasing prevalence worldwide and often treated with angiotensinconverting enzyme inhibitors (ACEi) or angiotensin receptor blockers (ARB). However, their efficacy is never be compared in heart failure patients, especially those who have co-morbid disease such as type 2 diabetes mellitus. Therefore, the aim of this study was to determine the effect of the two drugs in heart failure patients with type 2 diabetes mellitus. Methods: This meta-analysis was performed on research articles that focused on the drugs of heart failure patients published in PubMed, ProQuest and EBSCO database between 2008-2018. Pooled odds ratio (OR) are calculated using fixed and random effects models. Data were processed using Review Manager 5.3 (RevMan 5.3). Results: From total 209 articles, ten studies were met the criteria for the systematic review. The meta-analysis result showed that there was no difference in the effect of angiotensin-converting enzyme inhibitors versus angiotensin receptor blockers in heart failure patients with type 2 diabetes mellitus (RR = 1.73 [95% CI 0.88-3.40], p=0.11). However, heterogeneity test for studies (P-heterogeneity = <0.00001) showed there was some variation within the articles used which indicated heterogeneous research. Nevertheless, there was no publication bias in this study according to Egger’s test (p = 0.334) and Begg’s test (p = 0.180). Conclusion: This analysis confirmed there was no difference in the effect of angiotensin-converting enzyme inhibitors (ACEi) versus angiotensin receptor blockers (ARBs) in heart failure patients with type 2 diabetes mellitus.

bali medical journal

Comparing the effect of Angiotensin-Converting Enzyme Inhibitors versus Angiotensin Receptor Blockers in heart failure patients with type 2 diabetes mellitus: a systematic review