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Background: Nowadays, there are many researchers interested in the role of oxidative stress in the pathophysiological mechanism against erectile dysfunction. Oxidative stress occurs when there is an imbalance between pro-oxidant and the ability of the antioxidants to scavenge excess reactive oxygen species. The important role of oxidative stress in the pathophysiological mechanism of male and female infertility has been known. However, its role in maintaining the integrity structure of penile erectile tissue especially corpus cavernous smooth muscle cell has not been investigated comprehensively yet. In another side, testosterone has a critical role in maintaining the integrity of the penile

Testosterone increases corpus cavernous smooth muscle cells in oxidative stress-induced rodents (Sprague-Dawley)