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Today cancer is considered as the second cause of mortality in developed countries and fourth cause in the developing communities.1 Moreover, breast cancer is the commonest among women and the most important death caused due to cancer in this gender. According to the global studies, the prevalence of cancer is about 12.5 % and it’s estimated almost one out of eight women suffers from this type of cancer.2 As the chronic nature of cancer, these patients have to deal with long-term treatments. There have been great achievements in breast cancer treatment which have led to better tumor reactions to treatments and higher survival rates; however, these treatments bring about side effects such as swollen lymph, weakness, pain, numbness, and psychological-social disorders which can reduce cancer patients’ abilities significantly.3 In another word, patients with breast cancer face with numerous physical, psychological, and social stressful situations and feel insecure about their future, as cancer will bring in many changes in their life style, family conditions, and their social situation. These women experience treatments such as chemical therapy, radiotherapy, and surgery while they have to challenge all their unfavorable side effects such as hair loss, nausea, and sexual problems. Long-term treatment will threat the ability of these women in playing their social roles, as a housewife, mother or daughter, or as a community work force. High level of stress has a negative long-term effect on their self-esteem which eventually imposes unfavorable effects on family performance, marital role and quality of life. Cancer affects patients’ quality of life in different degrees and they experience numerous challenges in the field of emotional performance during treatment and after it.4 Therefore, investigating on quality of life in these patients is considered and important therapeutic and care indicator over the world.5 For More than a decade, the topic “quality of life” has been considered as an important issue in healthcare services, especially in the field of chronic diseases. During recent ABSTRACT

Investigating the Relationship between Self-efficacy and Quality of Life in Breast Cancer Patients Receiving Chemical Therapy