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Background: Diabetic retinopathy (DR) is the most common microvascular complication of diabetes. Several studies have emphasized the importance of platelet activation in the pathogenesis of DR. Platelet activation can be known by examination of platelet indices, ie Mean Platelet Volume (MPV), and Platelet Distribution Width (PDW). Objective: This study aims to determine the relationship between MPV, PDW and staging of DR, as one of the markers of disease progression. Methods: This study is a cross-sectional study at Sanglah Eye Clinic conducted from July to October 201. A total of 51 samples with DR were categorized based on the staging of DR, namely Non-Proliferative DR (NPDR) and Proliferative DR (PDR). Each group of staging was performed platelet indice (MPV and PDW) examination. Result: The correlation coefficient (r) was obtained -0.75 (p = 0.603) for MPV. Logistic regression test between MPV value and DR showed no association between MPV increasing and DR staging. B value 0.015, with Odd Ratio (OR) 1.015, 95% confidence interval and p value = 0.944. Spearman correlation test between PDW and DR staging obtained correlation coefficient (r) of = 0,006 (p=0,967). Logistic regression test between PDW value and diabetic staging of retinopathy showed no correlation between increasing PDW and degree of DR. B value 0.148, with Odd Ratio (OR) 1,160, 95% confidence interval and p value = 0,592. Conclusion : this study showed that is no correlation between Mean Platelet Volume (MPV), Platelet Distribution Width (PDW) and the degree of DR.

Non Prolipherative Diabetic Retinopathy Has Similar Platelet Morphology with Prolipherative Diabetic Retinopathy