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Medicinal treatment of liver fibrosis is still unsolved. According to literature data, plant extracts containing hydroxycinnamic acids inhibit experimentally induced liver fibrosis. Aim: The aim of this study was to provide data on the hydroxycinnamic acid content of medicinal plants, which can be applied in the adjuvant therapy of liver fibrosis. Methods: Content and composition of hydroxycinnamic acids from houseleek and seven known herbs were evaluated using spectrophotometry and high-performance liquid chromatography. Results: Hydroxycinnamic acid content was found to be high in Lamiaceae herbs, but it was lower in houseleek. Rosmarinic acid as the main compound was detected in all herb samples. Conclusions: Besides hydroxycinnamic acids, houseleek contains high amounts of antioxidant polyphenols, and its pharmacological effect is presumed to be attributed to synergism of all of these compounds. The hydroxycinnamic acid content of the herbs investigated was remarkable, therefore, the results support their dietary application in patients with chronic liver disease. Orv. Hetil., 2012, 153, 948–953.

Importance of dietary hydroxycinnamic acids in the therapy of liver fibrosis