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Introduction: In recent years, many papers analyzed the relationship between serum vitamin D 3  level and the frequency and activity of various diseases at least partially attributed to immune mechanisms. Aim: We looked for correlations among the number and location of edematous episodes occurring in patients with hereditary angioedema due to C1-inhibitor deficiency (C1-INH-HAE) and the quantity of the C1-inhibitor used for supplementation as well as the vitamin D 3  levels of patients. Method: We measured vitamin D 3  levels in 118 of the 175 C1-INH-HAE patients of the National Angioedema Reference Center during the winter–spring (n = 111) and the summer–autumn periods (n = 105) in 2013–2014. Complement levels and clinical data were extracted from the National Angioedema Registry and from patient diaries. Results: The proportion of vitamin D 3  deficient patients (serum level &lt;20 ng/ml) was approximately 59.5% during winter–spring, 27.6% in summer–autumn, and 23.5% during both periods. There was a significant difference between vitamin D 3  serum levels measured in the winter–spring or in the summer–autumn months (p&lt;0.0001). The same applies to the number of the vials of C1-inhibitor concentrate administered as acute treatment for angioedema attacks (p = 0.01). In any season, vitamin D 3  level did not correlate with the number of attacks experienced by the patients during the given period or of the vials of C1-inhibitor concentrate administered. Conclusions: We could not demonstrate a relationship between vitamin D 3  level and the frequency or location of edematous episodes in HAE patients. The need for treatment (as reflected by the number of the vials administered) was higher in the winter–spring period. As vitamin D 3  deficiency was more severe than expected in our patients, supplementation is clearly necessary. Orv Hetil. 2019; 160(25): 987–993.

A D3-vitamin-szint és a betegség súlyossága közötti kapcsolat vizsgálata herediter angioödémában

A D₃-vitamin-szint és a betegség súlyossága közötti kapcsolat vizsgálata herediter angioödémában