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Host immune responses are pivotal for combating enteropathogenic infections. We here assessed the impact of the innate receptor nucleotide oligomerization domain protein 2 (NOD2) in murine Campylobacter jejuni -infection. Conventionally colonized IL-10 -/- mice lacking NOD2 and IL-10 -/- controls were perorally challenged with C. jejuni strain 81-176 and displayed comparable pathogenic colonization of intestines until day 14 postinfection (p.i.). Whereas overall intestinal microbiota compositions were comparable in naive mice, NOD2 -/- IL-10 -/- mice exhibited less fecal bifidobacteria and lactobacilli than IL-10 -/- counterparts after infection. Interestingly, NOD2 -/- IL-10 -/- mice were clinically more compromised during the early phase of infection, whereas, conversely, IL-10 -/- animals exhibited more frequently bloody feces lateron. While colonic apoptotic cell and T lymphocyte numbers were comparable in either C. jejuni -infected mice, B lymphocytes were lower in the colon of infected NOD2 -/- IL-10 -/- mice versus controls. At day 14 p.i., colonic TNF and IL-23p19 mRNA levels were upregulated in NOD2 -/- IL-10 -/- mice only. Translocation rates of intestinal commensals to mesenteric lymphnodes and extra-intestinal compartments including liver and kidney were comparable, whereas viable bacteria were more frequently detected in spleens derived from IL-10 -/- as compared to NOD2 -/- IL-10 -/- mice. In conclusion, NOD2 is involved during C. jejuni infection in conventionally colonized IL-10 -/- mice in a time-dependent manner.

european journal of microbiology and immunology

Microbiota composition and immune responses during <i>Campylobacter jejuni</i> infection in conventionally colonized IL-10<sup>−/−</sup> mice lacking nucleotide oligomerization domain 2

Microbiota composition and immune responses during Campylobacter jejuni infection in conventionally colonized IL-10−/− mice lacking nucleotide oligomerization domain 2

Microbiota composition and immune responses during Campylobacter jejuni infection in conventionally colonized IL-10^−/− mice lacking nucleotide oligomerization domain 2