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Background and aim  This study was carried out to investigate antiplasmodial activities of  Diospyros mespiliformis  ( DM ) and  Mondia whitei  ( MW ) in  Plasmodium berghei -infected mice.    Materials and methods  Air-dried stem of  DM  and root of  MW  were soaked in methanol, decanted and concentrated to give extracts. Parts of these extracts were partitioned successively to give dichloromethane, ethylacetate and methanol fractions. Mice (18 ± 3 g) were infected with  Plasmodium berghei -infected erythrocytes from a donor mouse and were treated with the extracts, while the drug control group received 10 mg/kg body weight of artesunate and the parasitized control received the vehicle (5% v/v DMSO). Percentage parasitemia and clearance were estimated from thin films of blood smear. Hematological parameters were determined using standard methods. Both extracts were also tested on  in vitro  inhibition of β-hematin formation.    Results, discussion and conclusion  Results showed that  DM  had the least percentage parasitemia (0.67%) and highest percentage parasite clearance (84.7%) while the  MW  had 0.89% percentage parasitemia and 79.7% clearance at the highest dose used after the seventh day relative to untreated control. The cell free antiplasmodial activity of the fractions and extracts of both  DM  and  MW  revealed that  DM  significantly inhibited β-hematin formation than  MW . The packed cell volume, white blood cell count, Lymphocyte, Eosinophil, Monocyte and Neutrophil significantly increased in the treated groups compared with the control. The results showed that the  DM  had higher antiplasmodial activity.

interventional medicine and applied science/interventional medicine and applied science

ln vitro inhibition of beta-hematin formation and in vivo effects of Diospyros mespiliformis and Mondia whitei methanol extracts on chloroquine-susceptible Plasmodium berghei-induced malaria in mice