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Helicobacter pylori  is a common pathogen causing gastric inflammation and malignancy. Fetuin-A is a multifunctional protein that is involved in the regulation of calcification, insulin resistance and inflammation. Reports on serum levels of fetuin-A in acute  H. pylori  infection are contradictory. We intended to see whether  H. pylori  post-infection status has a long-term effect on serum fetuin-A levels in a well-characterized series of systemic lupus erythematosus cases. In this cross-sectional study 117 patients with systemic lupus erythematosus were enrolled. Helicobacter infection status and serum fetuin-A concentration were determined by ELISA and radial immunodiffusion, respectively.  H. pylori  positive patients had higher serum fetuin-A concentration than negative ones: 517 (456–603) vs. 476 (408–544) mg L −1 , median (25–75% percentiles),  P  = 0.020. No other parameters differed between these groups. During univariate regression analysis fetuin-A levels were associated with Erythrocyte sedimentation rate (ESR), White blood cell count (WBC), C-reactive protein (CRP), serum total protein, albumin, and the SLEDAI index at the time of diagnosis but only serum albumin remained a significant determinant in multivariate regression study.

Serum fetuin-A level is independent of Helicobacter pylori postinfection status in systemic lupus erythematosus