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Systemic (intramuscular, i.m.) vs. local (intracisternal, IC) routes of spiramycin-based drying-off therapy were compared for efficacy on 65 Staphylococcus aureus infected udder quarters of 38 dairy cows. Single-dose (30,000 IU/kg) i.m. treatment (single i.m. group) resulted in a similarly low bacteriological recovery rate (14%) as seen in the untreated controls (18%). I.m. treatment (30,000 IU/kg) on 4 consecutive days (4 i.m. group) resulted in significantly higher quarter-based recovery rates than that in the single i.m. group. The bacteriological recovery rates obtained in the intracisternal and 4 i.m. groups were quite similar but remained below 50%. Based on these findings as well as on the high cost of the repeated intramuscular treatment regime there is no reason to give extra preference to the systemic application of spiramycin at drying off in the practice.

Bacteriological recovery after intramuscular or intracisternal spiramycin-based drying-off therapy