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PURPOSE: The purpose of the present study was to evaluate the effects of booster vaccination of horses with multivalent vaccine against equine herpes virus 4/1 and equine influenza virus (EIV) on some acute phase response indices – classical pathway of complement activation (CPCA), erythrocyte sedimentation rate (ESR) and some clinical parameters. METHODS: Nine Hanoverian geldings were divided into two groups: group А – 3 non-vaccinated animals and group B – 6 revaccinated animals. Horses from group B were vaccinated one year ago against EHV 4/1 and EIV. CPCA was assayed as per the method of Mayer, modified for horses and ESR – by the method of Westergren. Pulse rate (PR), respiratory rate (RR) and rectal temperature (RT) were also monitored throughout the 14-day experimental period. RESULTS: In horses from group B, a substantial increase in haemolytic activity of CPCA was established (24 -72 h), enhanced ESR (by the 72 nd h), accelerated PR by the 24 th h within the reference range, no statistically significant changes in RR and absence of fever. CONCLUSIONS: The changes in acute phase response parameters CPCA, ESR, PR, RR and RT after revaccination of horses could provide information for their health status with respect to their performance and participation in competitions.

Laboratory And Field Studies On Acute Phase Response Of Horses After Vaccination Against Equine Influenza Virus And Equine Herpes Virus 4/1