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The existing therapeutic approaches – radiation therapy and conventional chemotherapy of cancer, suffer of serious side-effects as a result of increased generation of reactive oxygen and nitrogen species (ROS/RNS) in non-cancer cells and tissues. Currently, the development of oxidative stress in non-cancer tissues of cancer-bearing organism is a serious problem of cancer therapy. It is necessary to ask about a combination of substances expressing a therapeutic synergism as a result of differentiated effects on cancer and normal cells: substances with increased ROS/RNS-scavenging properties targeting normal cells and substances with increased ROS/RNS-generating properties targeting cancer cells. In this context, the redox-modulators are one of the most attractive candidates. The present review outlines the basic principle of this novel therapeutic strategy, focusing on nitroxide derivatives as one of the most promising redox-modulators with antioxidant ability.

Redox-modulating and/or antioxidant properties of niroxides - a potential reason for decreasing side-effects of cancer therapy