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Acute-phase response is most critical for the attenuation of the strong inflammatory response induced by bacterial opportunist Pseudomonas aeruginosa. The aim of the present study was to evaluate the acute-phase response in experimental Pseudomonas aeruginosa skin infection, by measuring changes in fibrinogen concentration (a positive acute-phase protein, APP) and activity of arylesterase (ARE – a negative APP). We also aimed to evaluate the effect of therapy with phytopreparation Feverfew, containing the active component parthenolide, which has anti-inflammatory properties. Fifteen male mongrel dogs at 2–5 years of age were divided into three groups: group 0 (n=5) with infection induced by subcutaneous injection of bacterial Pseudomonas aeruginosa culture 1×10 CFU/mL; group I (n=5) – infected and treated with Feverfew (standardised extract, active principle parthenolide 0.7%  Nature’s Way, USA), by application of 1 capsule at 12-hour intervals. The per os treatment began on post infection hour 4 and continued for 6 days. Dogs from group C (n=5) were controls. Plasma fibrinogen and serum ARE activity were assayed before infection and on 4, 24, 48 and 72 hour and on 7, 10 and 14 day after infection. The results suggested that fibrinogen levels in dogs from group 0 increased on p.i. hour 24 vs baseline, attained a peak on hour 48 (P<0.001), and persisted high on hour 72. Infected dogs treated with Feverfew (group І) exhibited a similar time course of changes in fibrinogen levels, but the numeric values were lower compared to those of group 0 (P<0.05). ARE activity in experimental animals did not change significantly and was similar to control values.

bulgarian journal of veterinary medicine

Acute-phase response and the effect of phytopreparation Feverfew (Tanacetum parthenium) in dogs with experimental Pseudomonas aeruginosa skin infection