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Leishmania es un protozoario patogeno, que transita durante su ciclo de vida desde el intestino de su vector hasta un compartimiento fagolisosomal al interior de su celula hospedera, el macrofago. Durante este recorrido el parasito esta expuesto a ambientes que cambian en temperatura, pH y presumiblemente osmolaridad. Para su supervivencia, Leishmania debe hacer ajustes para adaptarse y la expresion de canales de cloruro ha sido implicada en estos. Basandose en los antecedentes de nuestro grupo de investigacion, que registro corrientes de cloruro voltaje dependientes luego de la inyeccion de mRNA de promastigotes de Leishmania en ovocitos de Xenopues laevis, se postula que estas son el resultado de la actividad de proteinas CLC. Se mencionan algunas bases moleculares de la adaptacion de este parasito con enfasis en transportadores, regulacion de calcio, pH y osmolaridad. Con base en datos del grupo se argumenta que la osmolaridad de la vacuola parasitofora es alta. Ademas se da evidencia de la transcripcion en promastigotes de tres genes que codificarian CLC putativos, y se postulan funciones potenciales que llevarian a cabo en los dos estadios del parasito. Abstract Leishmania is a protozoan pathogen that transits during its lifecycle from the gut of the vector to a phagolysosomal compartment within its host cell, the macrophage. During this journey, the parasite is exposed to environments that change in temperature, pH and osmolarity. For their survival, Leishmania must make adjustments to adapt and expression of chloride channels has been involved in these. Based on our research group results: reported voltage-dependent chloride currents after mRNA injection of promastigotes of Leishmania in Xenopus laevis oocytes, it is postulated that these are the result of CLC protein activity. Some molecular bases of adaptation of this parasite are mentioned with emphasis on regulation of calcium, pH and osmolarity. Based on data from our group it is argued that the osmolarity of the parasitophorous vacuole is high. In addition, evidence of the transcription in promastigotes of three genes that encode putative CLC is given and potential functions that take place in the two stages of the parasite are postulated.

¿ESTÁN LOS CLC DE LEISHMANIA ASOCIADOS CON LA ADAPTACIÓN DEL PARÁSITO A CAMBIOS DE pH Y/O DE OSMOLARIDAD?