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We report the rare case of a primary epithelioid angiosarcoma of the femur and tibia. Only a small fraction of primary angiosarcomas occur in bone, and evenmore of a rarity is the presence of the epithelioid variant in bone. The epithelioid variant consists of large cells with epithelioid features that can easily be mistaken histologically for a poorly differentiated carcinoma due to the epithelioidmicroscopic appearanceof the neoplasm, as was the case with the initial diagnosis for the patient presented. As such, immunostains are imperative tomaking the correct diagnosis of an epithelioid angiosarcoma.

Primary Epithelioid Angiosarcoma of the Femur and Tibia: A Rapidly Aggressive Course