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The article presents studies on the use of hormonal contraceptive drugs based on megestrol acetate and comparisons with the developed by us comprehensive drug scheme of contraception. For the experiments were selected 115 clinically healthy female cats aged 1.5 to 6 years and 79 bitches aged 2 to 7 years. They were divided into two groups, control and experimental. Animals of the control group were given only the contraceptive drug on the basis of megestrol acetate, and the animals of the experimental group prescribed a contraceptive drug on the basis of megestrol acetate in combination with homoeopathic preparations «Ovaryovit» and «Mastometrin», which were injected intramuscularly in the dosage for middle and large dogs 2–4 ml, female cats and small breeds of dogs 0.5–2 ml, three times per week, course of treatment six weeks. Diagnosis of the reproductive system and the mammary gland of females of the control and experimental groups of animals for the presence of pathology were conducted one year after the administration of drugs by ultrasound and clinical examination. As a result of the research, it was found that as a result of the comprehensive use of the contraceptive drug on the basis of megestrol acetate with homoeopathic drugs «Ovaryovit» and «Mastometrin», the percentage of diseased animals in the experimental group (disorders at the reproductive system and mammary gland) among cats was less than 16% in comparison with control (P ≤ 0.005). The disorders at the reproductive system and mammary gland in the experimental group of cats were reversible and did not require surgical intervention. In the experimental group of bitches, the percent of animals with disorders in reproductive system and mammary gland were smaller by 22.4% compared with the control group of animals (P ≤ 0.005). And also all disorders at the reproductive system and mammary gland in the experimental group of cats were reversible and did not require surgical intervention. The use of drug contraception in combination with homeopathic remedies for the reproductive system of animals showed a significant reduction in the incidence of pathology of the reproductive system and the mammary gland in cats and females. The use of homeopathic remedies, simultaneously with the setting of synthetic progestogens, reduced the negative impact on the reproductive system and mammary gland of female animals (cats and bitches) with complete suppression of estrus.

Method of comlex medicamental contraception in females of domestic animals