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An important direction in the improvement of veterinary and prophylactic measures is the development and introduction into production of new preparations having bioactive properties and regulatory influence on the growth and development of birds, the intensity of metabolic processes, the ability to enhance the functional activity of organs and systems of the body, increase the level of natural resistance of the organism animals. The purpose of research was to study the effect of nanomicroelement feed additive «Microstimulin» and means Bioglobin on the resistance and metabolism of chicken broilers at experimental pseudomonosis. The investigated means «Microstimulin» and Bioglobin were given to chickens aged 14 days (cross Cobb 500) per os 1 time per day in a dose of 1 ml/l and 1 ml/kg with drinking water for 14 days. At day 12 of the experiment, we infected chickens with culture P. aeruginosa intraperitoneally at a dose of 300,000 CFU/ml to modeled pseudomonas infection groups. Slaughter of chickens was carried out in accordance with the principles of humanity by decapitation method on the 15th day of the experiment in 29 day old chicks. The determination of action of the «Microstimulin» and Bioglobin on biochemical processes in the organism of conditionally healthy poultry and at experimental pseudomonas infection was carried out in a complex manner, based on the indicators of congenital immunity, protein metabolism and activity of hepatospecific enzymes AST and ALT. The «Microstimulin» and Bioglobin has a pronounced influence on metabolic processes, in particular protein metabolism, and on the state of the system of congenital immunity of poultry. In the organism of intact bird, investigated means causes similar changes in the level of such mediators of the immune response, as CIC average molecular weight and seromucoids. The use of «Microstimulin» induces pronounced changes in the level of the protein through increased globulin fractions, and increased lysozyme activity. The action of Bioglobin is accompanied by a redistribution of protein fractions towards a slight increase in the synthesis of albumin and γ-globulin, the accumulation of the protein metabolism fractions in the serum, and an increase of lysozyme activity. The investigated means also helps to reduce the manifestations of pathogenetic effects of P. aeruginosa on the bird organism.

Influence of «Microstimulin» and Bioglobin on immunoreactivity status and biochemical processes in chicken broilers at experimental pseudomonosis